Little is known about de Wilde's life. In his youth, he studied theology probably under Gregorio Abbatini in St. Andrew's Abbey. In the 1640's he was taught mathematics and physics in Naples and Bologna.
De Wilde returned in Brunant somewhen between 1647 and 1650. He started his reasearch under the patronage of Willem II and was offered the seat of physics at the Grijzestad University in 1659. He had a good relationship with Willem II, but not with Karl Van Draak. It is said that Van Draak respected de Wilde for his knowledge, but suspected him due to his friendship and closeness to his predecessor.
De Wilde died in 1677, after a long illness. According to the tradition his last words were: "Pursue knowledge in the name of God".
In 1653, de Wilde published Arithmetica Logarithmica, containing the logarithms of thirty thousand natural numbers to fourteen decimal places (1-20,000 and 90,001 to 100,000).
He investigated the free fall of objects, confirming that the distance of fall was proportional to the square of the time taken. He also made a calculation of the gravitational constant by recording the oscillations of an accurate pendulum.